Single runes can drop anywhere during Diablo 2: Resurrected, starting with Normal difficulty, and progressing on to Hell difficulty d2r items for sale. Runes can be socketed, much like gems, and you can put them into equipment with sockets to benefit from their effects.
However, the true power of runes is when you combine them with a set order to create the context of a particular item. Runewordsas they're known, are some of the most powerful items in the game, and are right behind established items and specials. A full list of runewords is available in the next section.
Runes can also be used in certain Horadric Cube recipes. For instance, you can mix Ral Ral rune and a damaged piece equipment to repair it. This is a fantastic option when you're in a pinch of gold and aren't able to pay for repairs from a vendor. Runes can also be combined together in the Horadric Cube.
This is popularly referred to "cubing up" and it is a common way to gain access to the next rune without having to find an alternative in the wilderness. For instance, if can find three El runes and need an Eld rune, you can place the three El runes in the cube by pressing the transmute button. Out will pop the Eld rune diablo II resurrected items. This recipe for upgrading can be found in the rune charts below.